Elizabeth C M de Lange
Leiden University, Netherlands
Biography
Elizabeth C M de Lange has obtained her PhD from Leiden University in 1993 and was tenured in 2004. She is the Head of the Translational Pharmacology Group at Leiden Academic Center for Drug Research (LACDR). Her ultimate aim is to aid in the prediction of the dose-response relationship of CNS drugs in the clinical setting, on the basis of preclinical data (translational research). Her research involves the identification and characterization of the rate and extent of key factors in the dose-response relationship of CNS drugs in health and CNS disorders. It involves the use of advanced preclinical research (e.g.m including microdialysis, EEG monitoring, PET scanning) and advanced pharmacometrics (Systems Pharmacology). She has published more than 100 papers and book chapters and she is a frequently invited lecturer. Furthermore, she is a Member of the Editorial Board of FBCNS, co-founded and (co-) chaired several of the International Symposia on Microdialysis in Drug R&D. She is an AAPS Fellow since 2013. Her company In Focus provides courses, training and advice on microdialysis, pharmacokinetics, BBB transport and CNS target site distribution and effects and systems pharmacology.